DNA nanoparticles with core–shell morphology
نویسندگان
چکیده
منابع مشابه
DNA nanoparticles with core-shell morphology.
Mannobiose-modified polyethylenimines (PEI) are used in gene therapy to generate nanoparticles of DNA that can be targeted to the antigen-presenting cells of the immune system. We report that the sugar modification alters the DNA organization within the nanoparticles from homogenous to shell-like packing. The depth-dependent packing of DNA within the nanoparticles was probed using AFM nano-inde...
متن کاملTuning Carbon Content and Morphology of FeCo/Graphitic Carbon CoreShell Nanoparticles using a SaltMatrixAssisted CVD Process
Among various magnetic nanoparticles that have been studied for potential biomedical applications, FeCo nanoparticles are promising candidates because of their high saturation magnetization and high Curie temperature. [ 3–5 ] However, the ease of oxidation, dissolution in acidic environments, and potential toxicity of these materials in their native state restrict their use in biomedical applic...
متن کاملControlling and switching the morphology of micellar nanoparticles with enzymes.
Micelles were prepared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A, protein phosphatase-1, and matrix metalloproteinases 2 and 9. We examine reversible switching of the morphology of these micelles through a phosphorylation-dephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, th...
متن کاملProbing DNA assembly into nanoparticles with short DNA
DNA is an anionic polyelectrolyte, which occupies a large volume in salt free solution due to the coulomb repulsion between the charged groups. In the presence of high valence cations, DNA condenses into nanoparticles. DNA nanoparticles have generated a lot of interest as a preferred vehicle for delivering therapeutic DNA in gene therapy. The efficiency of gene delivery is determined by stabili...
متن کاملDNA as a Powerful Tool for Morphology Control, Spatial Positioning, and Dynamic Assembly of Nanoparticles
CONSPECTUS: Several properties of nanomaterials, such as morphologies (e.g., shapes and surface structures) and distance dependent properties (e.g., plasmonic and quantum confinement effects), make nanomaterials uniquely qualified as potential choices for future applications from catalysis to biomedicine. To realize the full potential of these nanomaterials, it is important to demonstrate fine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Soft Matter
سال: 2014
ISSN: 1744-683X,1744-6848
DOI: 10.1039/c4sm00908h